Gene
stag1a
- ID
- ZDB-GENE-070912-448
- Name
- STAG1 cohesin complex component a
- Symbol
- stag1a Nomenclature History
- Previous Names
-
- stag1
- si:dkey-223d7.4 (1)
- wu:fc28h03
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to localize to chromatin; cohesin complex; and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 47. Orthologous to human STAG1 (stromal antigen 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la010827Tg | Transgenic insertion | Unknown | Unknown | DNA | |
nz204 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
sa12166 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa13423 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa17076 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19759 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa25109 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-stag1a | (2) | |
MO1-stag1a | N/A | Ketharnathan et al., 2020 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant intellectual developmental disorder 47 | Alliance | Intellectual developmental disorder, autosomal dominant 47 | 617635 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
stag1a-201
(1)
|
Ensembl | 3,777 nt | ||
mRNA |
stag1a-202
(1)
|
Ensembl | 7,677 nt | ||
mRNA |
stag1a-203
(1)
|
Ensembl | 3,792 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-223D7 | ZFIN Curated Data | |
Contains | SNP | rs3727630 | ZFIN Curated Data | |
Encodes | EST | fc28h03 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001362340 (1) | 7614 nt | ||
Genomic | GenBank:CR786576 (1) | 202469 nt | ||
Polypeptide | RefSeq:NP_001349269 (1) |
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Ketharnathan, S., Labudina, A., Horsfield, J.A. (2020) Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:617545
- Kasap, M., Rajani, V., Rajani, J., Dwyer, D.S. (2018) Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability. Schizophrenia research. 202:120-128
- Yao, L., Chen, J., Wu, X., Jia, S., Meng, A. (2017) Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Human molecular genetics. 26(21):4168-4180
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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