Gene

nlrc8

ID

ZDB-GENE-070912-363

Name

NLR family CARD domain containing 8

Symbol

nlrc8 Nomenclature History

Previous Names

NACHT, LRR and PYD domains-containing protein 3 isoform X2 (1)
si:dkey-121n8.4

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have ATP binding activity. Predicted to be involved in intracellular signal transduction.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nlrc8 Human Ortholog

No data available

Associated With nlrc8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007111	NACHT nucleoside triphosphatase
Domain	IPR029495	NACHT-associated domain
Domain	IPR041075	NOD1/2, winged helix domain
Domain	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2
Family	IPR051261	NOD-like receptor (NLR)
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR006553	Leucine-rich repeat, cysteine-containing subtype

Domain Details Per Protein

Protein	Length	Leucine-rich repeat	Leucine-rich repeat, cysteine-containing subtype	Leucine-rich repeat domain superfamily	NACHT-associated domain	NACHT, LRR and PYD domains-containing protein, helical domain HD2	NACHT nucleoside triphosphatase	NOD1/2, winged helix domain	NOD-like receptor (NLR)	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9PLT8 InterPro	1017
UniProtKB:A0A8M9NYR7 InterPro	846
UniProtKB:A0A8M9PIU3 InterPro	960

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	nlrc8-201 (1) Ensembl	Ensembl		4,552 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations