Gene
vav3b
- ID
- ZDB-GENE-070912-251
- Name
- vav 3 guanine nucleotide exchange factor b
- Symbol
- vav3b Nomenclature History
- Previous Names
-
- fk86g11
- si:ch211-255p13.2
- wu:fk86g11
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell migration and regulation of GTPase activity. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3).
- Genome Resources
- Note
-
There are some attribution errors between ntng1b (ZDB-GENE-070912-250) and vav3b (ZDB-GENE-070912-251). ENSDARG00000073713 should only be attributed to ntng1b. ENSDARG00000073713 is mistakingly attributed to both genes. vab3b should only be associated with ENSDARG00000075962. ntng1b should be associated with these transcripts: "vav3b"-201, "vav3b"-202 and "vav3b"-203 vav3b should be associated with these transcripts: vav3b-204, vav3b-205, vav3b-206 and vav3b-207
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR022613 | Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain |
| Domain | IPR035734 | VAV3 protein, second SH3 domain |
| Domain | IPR037832 | Vav, PH domain |
| Domain | IPR055251 | SOS1/NGEF-like, PH domain |
| Family | IPR003096 | Smooth muscle protein/calponin |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Length | Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain | Calponin homology domain | CH domain superfamily | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Smooth muscle protein/calponin | SOS1/NGEF-like, PH domain | VAV3 protein, second SH3 domain | Vav, PH domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:X1WEX4
|
822 | ||||||||||||||||
|
UniProtKB:A0A8M2BAQ7
|
853 | ||||||||||||||||
|
UniProtKB:B0S6C8
|
826 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance