Gene

c8b

ID

ZDB-GENE-070912-163

Name

complement component 8, beta polypeptide

Symbol

c8b Nomenclature History

Previous Names

si:ch211-188c16.3
wu:fi18d09

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to be involved in complement activation. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Is expressed in liver. Orthologous to human C8B (complement C8 beta chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Takada et al., 2017

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c8b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type II complement component 8 deficiency	Alliance	C8 deficiency, type II	613789

Associated With c8b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020863	Membrane attack complex component/perforin domain, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR020864	Membrane attack complex component/perforin (MACPF) domain
Domain	IPR048831	Complement components C8A/B/C6, EGF-like domain
Family	IPR001862	Membrane attack complex component/perforin/complement C9
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat