Gene

map3k3

ID

ZDB-GENE-070910-1

Name

mitogen-activated protein kinase kinase kinase 3

Symbol

map3k3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in anterior/posterior axis specification and heart development. Predicted to localize to cytoplasm. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Lu et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hong et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map3k3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cerebral cavernous malformations 5	621032

Associated With map3k3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000270	PB1 domain
Domain	IPR000719	Protein kinase domain
Domain	IPR034879	Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain
Domain	IPR053793	PB1-like domain
Family	IPR050538	Mitogen-activated protein kinase kinase kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase kinase kinase	Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain	PB1 domain	PB1-like domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily
UniProtKB:X1WGZ3 InterPro	620

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	map3k3-201 (1) Ensembl	Ensembl	1,881 nt	Select Tool ZFIN BLAST
mRNA	map3k3-202 (1) Ensembl	Ensembl	5,003 nt	Select Tool ZFIN BLAST
mRNA	map3k3-203 (1) Ensembl	Ensembl	1,827 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations