Gene
adam15
- ID
- ZDB-GENE-070809-4
- Name
- ADAM metallopeptidase domain 15
- Symbol
- adam15 Nomenclature History
- Previous Names
-
- si:dkey-24i24.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity and metalloendopeptidase activity. Predicted to be involved in innate immune response; integrin-mediated signaling pathway; and proteolysis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human ADAM15 (ADAM metallopeptidase domain 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAM, cysteine-rich domain | Disintegrin domain | Disintegrin domain superfamily | EGF-like domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | Reprolysin domain, adamalysin-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PUF0 | InterPro | 992 | ||||||||
| UniProtKB:A0A8M9PDM9 | InterPro | 969 | ||||||||
| UniProtKB:A0A8M9PN22 | InterPro | 902 | ||||||||
| UniProtKB:A0A8M2B4D4 | InterPro | 919 | ||||||||
| UniProtKB:E7FGJ0 | InterPro | 975 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adam15-201
(1)
|
Ensembl | 7,204 nt | ||
| mRNA |
adam15-202
(1)
|
Ensembl | 2,424 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24I24 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214147 (1) | 3850 nt | ||
| Genomic | GenBank:CR388365 (1) | 137882 nt | ||
| Polypeptide | UniProtKB:A0A8M1PUF0 (1) | 992 aa |
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63
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