Gene

edem3

ID

ZDB-GENE-070801-5

Name

ER degradation enhancer, mannosidase alpha-like 3

Symbol

edem3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose trimming involved in glycoprotein ERAD pathway. Predicted to localize to membrane. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With edem3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Congenital disorder of glycosylation, type IIv	619493

Associated With edem3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003137	PA domain
Domain	IPR037322	EDEM3, PA domain
Family	IPR001382	Glycoside hydrolase family 47
Family	IPR044674	ER degradation-enhancing alpha-mannosidase-like protein 1/2/3
Homologous_superfamily	IPR012341	Six-hairpin glycosidase-like superfamily
Homologous_superfamily	IPR036026	Seven-hairpin glycosidases
Homologous_superfamily	IPR046450	PA domain superfamily

Domain Details Per Protein

Protein	Length	EDEM3, PA domain	ER degradation-enhancing alpha-mannosidase-like protein 1/2/3	Glycoside hydrolase family 47	PA domain	PA domain superfamily	Seven-hairpin glycosidases	Six-hairpin glycosidase-like superfamily
UniProtKB:A0A8M2BEF7 InterPro	888
UniProtKB:A0A8N7T766 InterPro	870
UniProtKB:A0A8M2BE98 InterPro	872
UniProtKB:A0A8M3AV33 InterPro	886

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	edem3-201 (1) Ensembl	Ensembl		3,533 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations