Gene
alx4a
- ID
- ZDB-GENE-070712-3
- Name
- ALX homeobox 4a
- Symbol
- alx4a Nomenclature History
- Previous Names
-
- alx4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in cranial neural crest; head; head mesenchyme; and pectoral fin bud. Human ortholog(s) of this gene implicated in colorectal cancer; craniosynostosis; frontonasal dysplasia 2; hepatocellular carcinoma; and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Jang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
co3000 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
j320 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
j321b | Allele with one delins | Exon 1 | Unknown | CRISPR | |
j322a | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
j322b | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
j323a | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
j323b | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
j324 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
j325a | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
j325b | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-alx4a | Mitchell et al., 2021 | |
CRISPR2-alx4a | Jang et al., 2021 | |
CRISPR3-alx4a | Jang et al., 2021 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
frontonasal dysplasia 2 | Alliance | Frontonasal dysplasia 2 | 613451 |
parietal foramina | Alliance | Parietal foramina 2 | 609597 |
{Craniosynostosis 5, susceptibility to} | 615529 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired Homeobox Transcription Factors |
---|---|---|---|---|---|---|
UniProtKB:E7FGP3
|
368 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
TgBAC(alx4a:DsRed2) |
|
| 1 | (5) | |
Tg(cryaa:EGFP,hsp70l:alx4a) |
|
| 1 | (3) | |
Tg(mitfa:alx4a,EGFP) |
|
| 1 | Jang et al., 2021 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-107P11 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_001340930 (1) | 1883 nt | ||
Genomic | GenBank:BX510305 (1) | 156938 nt | ||
Polypeptide | UniProtKB:E7FGP3 (1) | 368 aa |
- Nguyen, T.T., Mitchell, J.M., Kiel, M.D., Kenny, C.P., Li, H., Jones, K.L., Cornell, R.A., Williams, T.J., Nichols, J.T., Van Otterloo, E. (2023) TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway. Development (Cambridge, England). 151(1):
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Jang, H.S., Chen, Y., Ge, J., Wilkening, A.N., Hou, Y., Lee, H.J., Choi, Y.R., Lowdon, R.F., Xing, X., Li, D., Kaufman, C.K., Johnson, S.L., Wang, T. (2021) Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish. Genome biology. 22:282
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Pini, J., Kueper, J., Hu, Y.D., Kawasaki, K., Yeung, P., Tsimbal, C., Yoon, B., Carmichael, N., Maas, R.L., Cotney, J., Grinblat, Y., Liao, E.C. (2020) ALX1-related frontonasal dysplasia results from defective neural crest cell development and migration. EMBO Molecular Medicine. 12(10):e12013
- Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
- Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
- Pashay Ahi, E., Walker, B.S., Lassiter, C.S., Jónsson, Z.O. (2016) Investigation of the effects of estrogen on skeletal gene expression during zebrafish larval head development. PeerJ. 4:e1878
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
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