Gene
arhgef18b
- ID
- ZDB-GENE-070705-462
- Name
- rho/rac guanine nucleotide exchange factor (GEF) 18b
- Symbol
- arhgef18b Nomenclature History
- Previous Names
-
- si:dkey-38o13.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have guanyl-nucleotide exchange factor activity. Involved in cilium movement. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Choksi et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Choksi et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Retinitis pigmentosa 78 | 617433 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000219 | Dbl homology (DH) domain |
Domain | IPR001849 | Pleckstrin homology domain |
Domain | IPR041020 | ARHGEF1-like, PH domain |
Family | IPR051632 | Rho guanine nucleotide exchange factor |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
Domain Details Per Protein
Protein | Length | ARHGEF1-like, PH domain | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Rho guanine nucleotide exchange factor |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8N7TD86
|
1059 | ||||||
UniProtKB:F1QCK8
|
1012 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
arhgef18b-201
(1)
|
Ensembl | 3224 nt | |
mRNA |
arhgef18b-202
(1)
|
Havana | 3618 nt | |
mRNA |
arhgef18b-203
(1)
|
Ensembl | 3302 nt |
Interactions and Pathways
No data available
Plasmids
No data available