Gene

arhgef12b

ID

ZDB-GENE-070705-36

Name

Rho guanine nucleotide exchange factor (GEF) 12b

Symbol

arhgef12b Nomenclature History

Previous Names

si:ch211-142p3.1
si:dkey-70k11.3 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Xie et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef12b Human Ortholog

No data available

Associated With arhgef12b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001478	PDZ domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR015212	Regulator of G protein signalling-like domain
Domain	IPR041020	ARHGEF1-like, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036305	RGS domain superfamily
Homologous_superfamily	IPR044926	RGS, subdomain 2

Domain Details Per Protein

Protein	Length	ARHGEF1-like, PH domain	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PDZ domain	PDZ superfamily	PH-like domain superfamily	Pleckstrin homology domain	Regulator of G protein signalling-like domain	RGS domain superfamily	RGS, subdomain 2
UniProtKB:A0A8M9Q1U7 InterPro	335
UniProtKB:A0A8M3ASS4 InterPro	1422
UniProtKB:A0A0R4IVL9 InterPro	1415
UniProtKB:A0A8M9PR72 InterPro	342
UniProtKB:A0A8M9PYG8 InterPro	307
UniProtKB:A0A8M3B9Z0 InterPro	1421
UniProtKB:A0A8M6Z0X2 InterPro	1387

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	arhgef12b-201 (1) Ensembl	Ensembl		6,952 nt	Select Tool ZFIN BLAST
mRNA	arhgef12b-202 (1) Ensembl	Ensembl		4,257 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations