Gene

abr

ID
ZDB-GENE-070705-146
Name
ABR activator of RhoGEF and GTPase
Symbol
abr Nomenclature History
Previous Names
  • im:6904863
  • si:ch211-253h3.1
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction and positive regulation of GTPase activity. Predicted to localize to membrane. Orthologous to human ABR (ABR activator of RhoGEF and GTPase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abr Human Ortholog
No data available
Associated With abr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000008 C2 domain
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR000219 Dbl homology (DH) domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR015123 Bcr-Abl oncoprotein oligomerisation
Domain IPR037865 Active breakpoint cluster region-related protein, PH domain
Family IPR037769 Abr/Bcr
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036481 Bcr-Abl oncoprotein oligomerisation domain superfamily
Domain Details Per Protein
Protein Length Abr/Bcr Active breakpoint cluster region-related protein, PH domain Bcr-Abl oncoprotein oligomerisation Bcr-Abl oncoprotein oligomerisation domain superfamily C2 domain C2 domain superfamily Dbl homology (DH) domain Dbl homology (DH) domain superfamily Guanine-nucleotide dissociation stimulator, CDC24, conserved site PH-like domain superfamily Pleckstrin homology domain Rho GTPase-activating protein domain Rho GTPase activation protein
UniProtKB:A0A8M2BFX1 315
UniProtKB:A0A8M2BJA8 814
UniProtKB:A0A8M6YYK4 643
UniProtKB:A5WUN5 324
UniProtKB:A0A8M1RSL2 859
UniProtKB:A0A8M2BJC9 1061
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA abr-201 (1) Ensembl 975 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations