Gene
bmpr2a
- ID
- ZDB-GENE-070618-1
- Name
- bone morphogenetic protein receptor, type II a (serine/threonine kinase)
- Symbol
- bmpr2a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables transforming growth factor beta receptor activity. Acts upstream of or within several processes, including BMP signaling pathway; circulatory system development; and fin regeneration. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood island; ovary; pronephric duct; tail bud; and trunk vasculature. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease 1. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-bmpr2a | (2) | |
| MO1-bmpr2a | N/A | Monteiro et al., 2008 |
| MO2-bmpr2a | N/A | (3) |
| MO3-bmpr2a | N/A | (4) |
| MO4-bmpr2a | N/A | (2) |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary pulmonary hypertension | Alliance | Pulmonary hypertension, familial primary, 1, with or without HHT | 178600 |
| primary pulmonary hypertension | Alliance | Pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated | 178600 |
| pulmonary venoocclusive disease 1 | Alliance | Pulmonary venoocclusive disease 1 | 265450 |
1 - 3 of 3
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Activin types I and II receptor domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BD77 | InterPro | 1013 | ||||||
| UniProtKB:Q288P3 | InterPro | 1003 | ||||||
| UniProtKB:A0A8M3AT76 | InterPro | 561 |
1 - 3 of 3
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bmpr2a-201
(1)
|
Ensembl | 4,414 nt | ||
| ncRNA |
bmpr2a-002
(1)
|
Ensembl | 455 nt | ||
| ncRNA |
bmpr2a-003
(1)
|
Ensembl | 488 nt |
1 - 3 of 3
Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-211E8 |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039817 (1) | 3902 nt | ||
| Genomic | GenBank:BX957337 (1) | 186218 nt | ||
| Polypeptide | UniProtKB:A0A8M2BD77 (1) | 1013 aa |
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Feng, Y., Zhang, J., Li, Y., Chen, G., Zhang, X., Ning, G., Wu, S. (2023) Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1. Gene. 898:148105
- Lalonde, R.L., Nicolas, H.A., Cutler, R.S., Pantekidis, I., Zhang, W., Yelick, P.C. (2023) Functional comparison of human ACVR1 and zebrafish Acvr1l FOP-associated variants in embryonic zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(5):605-628
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Cao, Z., Liu, G., Zhang, H., Wang, M., Xu, Y. (2022) Nox4 promotes osteoblast differentiation through TGF-beta signal pathway. Free radical biology & medicine. 193(Pt 2):595-609
- Wang, X., Ge, X., Qin, Y., Liu, D., Chen, C. (2022) Ifi30 Is Required for Sprouting Angiogenesis During Caudal Vein Plexus Formation in Zebrafish. Frontiers in Physiology. 13:919579
- Wang, J., Chen, Y., Zeng, Z., Feng, R., Wang, Q., Zhang, Q., Sun, K., Chen, A.F., Lu, Y., Yu, Y. (2021) HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Experimental cell research. 408(1):112831
- Zhong, S., Li, H., Wang, Y.S., Wang, Y., Ji, G., Li, H.Y., Zhang, S., Liu, Z. (2021) Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Communications biology. 4:318
- Rogers, K.W., ElGamacy, M., Jordan, B.M., Müller, P. (2020) Optogenetic investigation of BMP target gene expression diversity. eLIFE. 9:
- Zhang, Z., Wu, K., Ren, Z., Ge, W. (2020) Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signalling through Bmpr2a receptor. Development (Cambridge, England). 147(22):
1 - 10 of 35
Show