Gene
g6pd
- ID
- ZDB-GENE-070508-4
- Name
- glucose-6-phosphate dehydrogenase
- Symbol
- g6pd Nomenclature History
- Previous Names
-
- fj78b06
- si:dkey-90a13.8
- wu:fj78b06
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables UDP-glucose 6-dehydrogenase activity and glucose-6-phosphate dehydrogenase activity. Acts upstream of or within epiboly. Predicted to be active in cytosol. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 1 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 1, G6PD deficient | 300908 |
| {Resistance to malaria due to G6PD deficiency} | 611162 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hemolytic anemia | AB + CRISPR1-g6pd | standard conditions | Hwang et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019796 | Glucose-6-phosphate dehydrogenase, active site |
| Domain | IPR022674 | Glucose-6-phosphate dehydrogenase, NAD-binding |
| Domain | IPR022675 | Glucose-6-phosphate dehydrogenase, C-terminal |
| Family | IPR001282 | Glucose-6-phosphate dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Glucose-6-phosphate dehydrogenase | Glucose-6-phosphate dehydrogenase, active site | Glucose-6-phosphate dehydrogenase, C-terminal | Glucose-6-phosphate dehydrogenase, NAD-binding | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PWR3
|
513 | |||||
|
UniProtKB:A0A8M9PDT5
|
523 | |||||
|
UniProtKB:A0A8M2B959
|
534 | |||||
|
UniProtKB:E7FDY7
|
513 | |||||
|
UniProtKB:A0A8M3AY75
|
528 | |||||
|
UniProtKB:A0A8M9Q7P5
|
534 | |||||
|
UniProtKB:F6NHI0
|
523 | |||||
|
UniProtKB:A0A8M9Q3J7
|
528 |
Interactions and Pathways
No data available
Plasmids
No data available