Gene
g6pd
- ID
- ZDB-GENE-070508-4
- Name
- glucose-6-phosphate dehydrogenase
- Symbol
- g6pd Nomenclature History
- Previous Names
-
- fj78b06
- si:dkey-90a13.8
- wu:fj78b06
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables UDP-glucose 6-dehydrogenase activity and glucose-6-phosphate dehydrogenase activity. Acts upstream of or within epiboly. Predicted to be active in cytosol. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in anemia (multiple); cerebrovascular disease; diabetes mellitus; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa5035 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11949 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19319 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24272 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uto70 | Allele with one delins | Unknown | Unknown | CRISPR | |
| zf3820 | Allele with one delins | Unknown | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-g6pd | Hwang et al., 2018 | |
| CRISPR2-g6pd | Martínez-Navarro et al., 2020 | |
| CRISPR3-g6pd | Facchinello et al., 2022 | |
| CRISPR4-g6pd | (2) | |
| CRISPR5-g6pd | Tan et al., 2024 | |
| CRISPR6-g6pd | Tan et al., 2024 | |
| MO1-g6pd | N/A | (3) |
| MO2-g6pd | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 1 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 1, G6PD deficient | 300908 |
| {Resistance to malaria due to G6PD deficiency} | 611162 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hemolytic anemia | AB + CRISPR1-g6pd | standard conditions | Hwang et al., 2018 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019796 | Glucose-6-phosphate dehydrogenase, active site |
| Domain | IPR022674 | Glucose-6-phosphate dehydrogenase, NAD-binding |
| Domain | IPR022675 | Glucose-6-phosphate dehydrogenase, C-terminal |
| Family | IPR001282 | Glucose-6-phosphate dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glucose-6-phosphate dehydrogenase | Glucose-6-phosphate dehydrogenase, active site | Glucose-6-phosphate dehydrogenase, C-terminal | Glucose-6-phosphate dehydrogenase, NAD-binding | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PWR3 | InterPro | 513 | |||||
| UniProtKB:A0A8M9PDT5 | InterPro | 523 | |||||
| UniProtKB:A0A8M2B959 | InterPro | 534 | |||||
| UniProtKB:E7FDY7 | InterPro | 513 | |||||
| UniProtKB:A0A8M3AY75 | InterPro | 528 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-90A13 | ZFIN Curated Data | |
| Encodes | EST | fj78b06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021469916 (1) | 4264 nt | ||
| Genomic | GenBank:BX897727 (1) | 236277 nt | ||
| Polypeptide | UniProtKB:A0A8M2B959 (1) | 534 aa |
- Noble, A.R., Masek, M., Hofmann, C., Cuoco, A., Rusterholz, T.D.S., Özkoc, H., Greter, N.R., Phelps, I.G., Vladimirov, N., Kollmorgen, S., Stoeckli, E., Bachmann-Gagescu, R. (2024) Shared and unique consequences of Joubert Syndrome gene dysfunction on the zebrafish central nervous system. Biology Open. 13(11):
- Tan, V.W.T., Salmi, T.M., Karamalakis, A.P., Gillespie, A., Ong, A.J.S., Balic, J.J., Chan, Y.C., Bladen, C.E., Brown, K.K., Dawson, M.A., Cox, A.G. (2024) SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Developmental Cell. 59(7):898-910.e6
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Choi, S.S.A., Chan, H.H., Chan, C.M., Wang, X., Webb, S.E., Leung, K.W., Tsim, K.W.K., Miller, A.L. (2022) Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry. Journal of virology. 96(24):e0141822
- Facchinello, N., Astone, M., Audano, M., Oberkersch, R.E., Spizzotin, M., Calura, E., Marques, M., Crisan, M., Mitro, N., Santoro, M.M. (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nature metabolism. 4:123-140
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Masek, M., Etard, C., Hofmann, C., Hülsmeier, A.J., Zang, J., Takamiya, M., Gesemann, M., Neuhauss, S.C.F., Hornemann, T., Strähle, U., Bachmann-Gagescu, R. (2022) Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition. Nature communications. 13:1282
- Pagán, A.J., Lee, L.J., Edwards-Hicks, J., Moens, C.B., Tobin, D.M., Busch-Nentwich, E.M., Pearce, E.L., Ramakrishnan, L. (2022) mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. Cell. 185(20):3720-3738.e13
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Wang, X., Lin, S., Tang, R.W., Lee, H.C., Chan, H.H., Choi, S.S.A., Leung, K.W., Webb, S.E., Miller, A.L., Tsim, K.W. (2022) Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae. Phytomedicine : international journal of phytotherapy and phytopharmacology. 102:154154
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