Gene

ccnd2a

ID

ZDB-GENE-070424-30

Name

cyclin D2, a

Symbol

ccnd2a Nomenclature History

Previous Names

ccnd2
gb:bi671621
zgc:162280

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to contribute to protein kinase activity. Predicted to be involved in mitotic cell cycle phase transition; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to localize to cyclin-dependent protein kinase holoenzyme complex; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; invasive lobular carcinoma; prostate cancer; and transitional cell carcinoma. Is expressed in pharyngeal arch and testis. Orthologous to human CCND2 (cyclin D2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ccnd2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	615938

Associated With ccnd2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR048258	Cyclins, cyclin-box
Domain	IPR004367	Cyclin, C-terminal domain
Domain	IPR006671	Cyclin, N-terminal
Domain	IPR013763	Cyclin-like domain
Family	IPR039361	Cyclin
Family	IPR046965	Cyclin A/B-like
Homologous_superfamily	IPR036915	Cyclin-like superfamily

Domain Details Per Protein

Protein	Length	Cyclin	Cyclin A/B-like	Cyclin, C-terminal domain	Cyclin-like domain	Cyclin-like superfamily	Cyclin, N-terminal	Cyclins, cyclin-box
UniProtKB:A3KNN7 InterPro	298
UniProtKB:A0A8M2BLM1 InterPro	218

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ccnd2a-201 (1) Ensembl	Ensembl	1,293 nt	Select Tool
mRNA	ccnd2a-203 (1) Ensembl	Ensembl	287 nt	Select Tool
mRNA	ccnd2a-204 (1) Ensembl	Ensembl	476 nt	Select Tool
mRNA	ccnd2a-205 (1) Ensembl	Ensembl	727 nt	Select Tool
ncRNA	ccnd2a-002 (1) Ensembl	Ensembl	414 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations