Gene
kcnc2
- ID
- ZDB-GENE-070410-118
- Name
- potassium voltage-gated channel, Shaw-related subfamily, member 2
- Symbol
- kcnc2 Nomenclature History
- Previous Names
-
- zgc:162956
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within several processes, including potassium ion transport; protein homooligomerization; and regulation of monoatomic ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in axon; dendrite membrane; and neuronal cell body membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 103 | Alliance | Developmental and epileptic encephalopathy 103 | 619913 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR005821 | Ion transport domain |
| Family | IPR003968 | Potassium channel, voltage dependent, Kv |
| Family | IPR003974 | Potassium channel, voltage dependent, Kv3 |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Length | BTB/POZ domain | Ion transport domain | Potassium channel tetramerisation-type BTB domain | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv3 | SKP1/BTB/POZ domain superfamily | Voltage-dependent channel domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BBM3
|
593 | |||||||
|
UniProtKB:A0A8M6YXW1
|
572 | |||||||
|
UniProtKB:A0A8M3B8P1
|
589 | |||||||
|
UniProtKB:E0R7P8
|
597 |
Interactions and Pathways
No data available
Plasmids
No data available