Gene
ryk
- ID
- ZDB-GENE-070209-277
- Name
- receptor like tyrosine kinase
- Symbol
- ryk Nomenclature History
- Previous Names
-
- wu:fb37b12
- wu:fi05b06
- zgc:158381
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables Wnt-protein binding activity. Acts upstream of or within Wnt signaling pathway, calcium modulating pathway; convergent extension; and release of sequestered calcium ion into cytosol. Located in plasma membrane. Is expressed in heart tube; nervous system; notochord; post-vent region; and somite. Orthologous to human RYK (receptor like tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025466Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nce4g | Allele with one insertion | Exon 5 | Unknown | CRISPR | |
| os74 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 3 of 3
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ryk | (2) | |
| CRISPR2-ryk | (3) | |
| CRISPR4-ryk | Saraswathy et al., 2022 | |
| MO1-ryk | N/A | (2) |
| MO2-ryk | N/A | (2) |
| MO3-ryk | N/A | Macheda et al., 2012 |
| MO4-ryk | N/A | Macheda et al., 2012 |
| MO5-ryk | N/A | Saraswathy et al., 2022 |
1 - 8 of 8
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | WIF domain | WIF domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A2RRV7 | InterPro | 604 | |||||||
| UniProtKB:E7FAI5 | InterPro | 632 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-66I8 | ZFIN Curated Data | |
| Contains | SNP | rs3727980 | ZFIN Curated Data | |
| Encodes | EST | fb37b12 | ||
| Encodes | EST | fi05b06 | ||
| Encodes | cDNA | MGC:158381 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083826 (1) | 3186 nt | ||
| Genomic | GenBank:BX890558 (2) | 132028 nt | ||
| Polypeptide | UniProtKB:E7FAI5 (1) | 632 aa |
- Saraswathy, V.M., Kurup, A.J., Sharma, P., Polès, S., Poulain, M., Fürthauer, M. (2022) The E3 Ubiquitin Ligase Mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. eLIFE. 11:
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Boopathy, G.T.K., Kulkarni, M., Ho, S.Y., Boey, A., Chua, E.W.M., Barathi, V.A., Carney, T.J., Wang, X., Hong, W. (2017) Cavin-2 regulates the activity and stability of endothelial nitric oxide synthase (eNOS) in angiogenesis. The Journal of biological chemistry. 292(43):17760-17776
- Milash, B., Gao, J., Stevenson, T.J., Son, J.H., Dahl, T., Bonkowsky, J.L. (2016) Temporal Dysynchrony in brain connectivity gene expression following hypoxia. BMC Genomics. 17:334
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gao, X., Metzger, U., Panza, P., Mahalwar, P., Alsheimer, S., Geiger, H., Maischein, H.M., Levesque, M.P., Templin, M., Söllner, C. (2015) A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Cell Reports. 12(4):694-708
- Challa, A.K., and Chatti, K. (2013) Conservation and Early Expression of Zebrafish Tyrosine Kinases Support the Utility of Zebrafish as a Model for Tyrosine Kinase Biology. Zebrafish. 10(3):264-74
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Yang, H., Zhou, Y., Gu, J., Xie, S., Xu, Y., Zhu, G., Wang, L., Huang, J., Ma, H., and Yao, J. (2013) Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS One. 8(5):e64058
- Macheda, M.L., Sun, W.W., Kugathasan, K., Hogan, B.M., Bower, N.I., Halford, M.M., Zhang, Y.F., Jacques, B.E., Lieschke, G.J., Dabdoub, A., and Stacker, S.A. (2012) The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling. The Journal of biological chemistry. 287(35):29312-29323
1 - 10 of 15
Show