Gene
sos1
- ID
- ZDB-GENE-070209-128
- Name
- son of sevenless homolog 1 (Drosophila)
- Symbol
- sos1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity; guanyl-nucleotide exchange factor activity; and protein heterodimerization activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to localize to nucleosome. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| gingival fibromatosis | Alliance | Fibromatosis, gingival, 1 | 135300 |
| Noonan syndrome 4 | Alliance | Noonan syndrome 4 | 610733 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019804 | Ras guanine-nucleotide exchange factor, conserved site |
| Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
| Family | IPR002119 | Histone H2A |
| Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
| Homologous_superfamily | IPR009072 | Histone-fold |
| Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
| Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | Histone-fold | Histone H2A | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine-nucleotide exchange factor, conserved site | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A2RRV5
|
713 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sos1-201
(1)
|
Ensembl | 2,142 nt | ||
| mRNA |
sos1-202
(1)
|
Ensembl | 454 nt | ||
| mRNA |
sos1-204
(1)
|
Ensembl | 3,647 nt | ||
| mRNA |
sos1-205
(1)
|
Ensembl | 810 nt | ||
| mRNA |
sos1-206
(1)
|
Ensembl | 332 nt | ||
| mRNA |
sos1-207
(1)
|
Ensembl | 849 nt | ||
| ncRNA |
sos1-005
(1)
|
Ensembl | 505 nt |
Interactions and Pathways
No data available
Plasmids
No data available