Gene

nrxn1b

ID

ZDB-GENE-070206-3

Name

neurexin 1b

Symbol

nrxn1b Nomenclature History

Previous Names

nrxn1ba
nrxn1bb

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Predicted to be involved in cell adhesion. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).

Genome Resources

Note

nrxn1b has two isoforms, alpha (DQ641426) and beta (DQ641427).

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrxn1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Pitt-Hopkins-like syndrome 2	Alliance	Pitt-Hopkins-like syndrome 2	614325
		{Schizophrenia, susceptibility to, 17}	614332

Associated With nrxn1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR003585	Neurexin/syndecan/glycophorin C
Domain	IPR027789	Syndecan/Neurexin domain
Family	IPR050372	Neurexin-related cell adhesion and synaptic protein
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like domain	Laminin G domain	Neurexin-related cell adhesion and synaptic protein	Neurexin/syndecan/glycophorin C	Syndecan/Neurexin domain
UniProtKB:A0A8M3B4Y5 InterPro	1440
UniProtKB:A1XQX3 InterPro	448
UniProtKB:F1R7M4 InterPro	448
UniProtKB:A0A8M3AYS8 InterPro	1431
UniProtKB:A1XQX2 InterPro	1470
UniProtKB:F8W597 InterPro	1475
UniProtKB:A0A8M9PXV2 InterPro	217
UniProtKB:A0A8M3B7R4 InterPro	1457
UniProtKB:A0A8M3AYQ8 InterPro	1466