Gene
sgo1
- ID
- ZDB-GENE-070112-422
- Name
- shugoshin 1
- Symbol
- sgo1 Nomenclature History
- Previous Names
-
- sgol1 (1)
- zgc:158297
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within homeostasis of number of retina cells; regulation of heart contraction; and retinal pigment epithelium development. Predicted to be located in chromosome, centromeric region and nucleus. Is expressed in ciliary marginal zone; heart; and intestine. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sgo1 | (2) | |
| CRISPR2-sgo1 | Kamel et al., 2022 | |
| MO1-sgo1 | N/A | Chetaille et al., 2014 |
| MO2-sgo1 | N/A | Chetaille et al., 2014 |
| MO3-sgo1 | N/A | Chetaille et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chronic atrial and intestinal dysrhythmia | Alliance | Chronic atrial and intestinal dysrhythmia | 616201 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Shugoshin 1/2 | Shugoshin, C-terminal |
|---|---|---|---|
|
UniProtKB:A1L1S4
|
618 | ||
|
UniProtKB:A0A8M9PNJ5
|
561 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-359M17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158297 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080620 (1) | 2343 nt | ||
| Genomic | GenBank:CU596012 (1) | 111958 nt | ||
| Polypeptide | UniProtKB:A1L1S4 (1) | 618 aa |
- Kamel, S.M., Broekman, S., Tessadori, F., van Wijk, E., Bakkers, J. (2022) The zebrafish cohesin protein Sgo1 is required for cardiac function and eye development. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1357-1367
- Wang, J., Thomas, H.R., Chen, Y., Percival, S.M., Waldrep, S.C., Ramaker, R.C., Thompson, R.G., Cooper, S.J., Chong, Z., Parant, J.M. (2022) Reduced sister chromatid cohesion acts as a tumor penetrance modifier. PLoS Genetics. 18:e1010341
- Chetaille, P., Preuss, C., Burkhard, S., Côté, J.M., Houde, C., Castilloux, J., Piché, J., Gosset, N., Leclerc, S., Wünnemann, F., Thibeault, M., Gagnon, C., Galli, A., Tuck, E., Hickson, G.R., Amine, N.E., Boufaied, I., Lemyre, E., de Santa Barbara, P., Faure, S., Jonzon, A., Cameron, M., Dietz, H.C., Gallo-McFarlane, E., Benson, D.W., Moreau, C., Labuda, D., FORGE Canada Consortium, Zhan, S.H., Shen, Y., Jomphe, M., Jones, S.J., Bakkers, J., Andelfinger, G. (2014) Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature Genetics. 46(11):1245-9
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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