Gene
glis3
- ID
- ZDB-GENE-070112-2232
- Name
- GLIS family zinc finger 3
- Symbol
- glis3 Nomenclature History
- Previous Names
-
- wu:fa55a05
- zgc:158249 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Is expressed in several structures, including brain; otic vesicle; pectoral fin bud; pharyngeal endoderm; and pleuroperitoneal region. Orthologous to human GLIS3 (GLIS family zinc finger 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neonatal diabetes mellitus with congenital hypothyroidism | Alliance | Diabetes mellitus, neonatal, with congenital hypothyroidism | 610199 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2H2-type zinc-finger protein GLI-like | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:A1L1Q6
|
787 | |||
|
UniProtKB:A0A8M6Z1B7
|
804 | |||
|
UniProtKB:A0A8M9Q669
|
724 | |||
|
UniProtKB:A0A8M3B5Y0
|
803 | |||
|
UniProtKB:F1QB13
|
803 |
Interactions and Pathways
No data available
Plasmids
No data available