Gene
kdm6al
- ID
- ZDB-GENE-070112-2002
- Name
- lysine (K)-specific demethylase 6A, like
- Symbol
- kdm6al Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; germ cell migration; and heart development. Predicted to be part of MLL3/4 complex. Is expressed in blood island and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003347 | JmjC domain |
| Domain | IPR048560 | Lysine-specific demethylase 6A/B-like, GATA-like |
| Domain | IPR048562 | Lysine-specific demethylase 6A/B-like, C-terminal helical domain |
| Family | IPR051630 | Transcriptional Corepressor and Histone Demethylase |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR046941 | Lysine-specific demethylase 6, GATA-like domain superfamily |
| Repeat | IPR019734 | Tetratricopeptide repeat |
Domain Details Per Protein
| Protein | Length | JmjC domain | Lysine-specific demethylase 6A/B-like, C-terminal helical domain | Lysine-specific demethylase 6A/B-like, GATA-like | Lysine-specific demethylase 6, GATA-like domain superfamily | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Transcriptional Corepressor and Histone Demethylase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A1L1S9
|
1311 | |||||||
|
UniProtKB:A0A8M2BG42
|
1356 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
kdm6al-203
(1)
|
Ensembl | 5,865 nt | ||
| mRNA |
kdm6al-201
(1)
|
Ensembl | 4,921 nt | ||
| ncRNA |
kdm6al-003
(1)
|
Ensembl | 208 nt |
Interactions and Pathways
No data available
Plasmids
No data available