Gene
kdm2aa
- ID
- ZDB-GENE-061215-144
- Name
- lysine (K)-specific demethylase 2Aa
- Symbol
- kdm2aa Nomenclature History
- Previous Names
-
- jhdm1A-b (1)
- wu:fb76b11
- wu:fj11c04
- zgc:158441
- zgc:158606
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity; dioxygenase activity; and zinc ion binding activity. Involved in sex determination. Predicted to localize to nucleus. Used to study melanoma. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Scahill et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
melanoma | kdm2aasa9360/sa9360 | standard conditions | Scahill et al., 2017 |
melanoma | kdm2aasa898/sa898 | standard conditions | Scahill et al., 2017 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001810 | F-box domain |
Domain | IPR001965 | Zinc finger, PHD-type |
Domain | IPR002857 | Zinc finger, CXXC-type |
Domain | IPR003347 | JmjC domain |
Domain | IPR019787 | Zinc finger, PHD-finger |
Domain | IPR041070 | Jumonji, helical domain |
Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
Repeat | IPR006553 | Leucine-rich repeat, cysteine-containing subtype |
Domain Details Per Protein
Protein | Length | F-box domain | JmjC domain | Jumonji, helical domain | Leucine-rich repeat, cysteine-containing subtype | Leucine-rich repeat domain superfamily | Zinc finger, CXXC-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B724
|
1318 | ||||||||||
UniProtKB:A0A8M3AJC4
|
1239 | ||||||||||
UniProtKB:A0A0R4IH56
|
1295 | ||||||||||
UniProtKB:A0A8M3AK71
|
1265 | ||||||||||
UniProtKB:A0A8M3B2Q2
|
1293 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
kdm2aa-201
(1)
|
Havana | 3806 nt | |
mRNA |
kdm2aa-202
(1)
|
Havana | 4843 nt | |
mRNA |
kdm2aa-203
(1)
|
Ensembl | 5010 nt |
Interactions and Pathways
No data available
Plasmids
No data available