Gene

arhgef17

ID

ZDB-GENE-061207-93

Name

Rho guanine nucleotide exchange factor (GEF) 17

Symbol

arhgef17 Nomenclature History

Previous Names

fk53h05
si:ch211-248g20.5
si:zfos-900a7.1
wu:fk53h05

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in brain. Used to study intracranial aneurysm. Orthologous to human ARHGEF17 (Rho guanine nucleotide exchange factor 17).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Yang et al., 2018

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Yang et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef17 Human Ortholog

No data available

Associated With arhgef17 Via Experimental Models

Human Disease	Fish	Conditions	Citations
intracranial aneurysm	WT + MO2-arhgef17	standard conditions	Yang et al., 2018
intracranial aneurysm	WT + MO1-arhgef17	standard conditions	Yang et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR039919	Rho guanine nucleotide exchange factor 10/17
Homologous_superfamily	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Quinoprotein alcohol dehydrogenase-like superfamily	Rho guanine nucleotide exchange factor 10/17	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M1RJ80 InterPro	1035

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	arhgef17-201 (1) Ensembl	Ensembl		2,976 nt	Select Tool ZFIN BLAST
mRNA	arhgef17-202 (1) Ensembl	Ensembl		6,326 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations