Gene
myh7l
- ID
- ZDB-GENE-061027-393
- Name
- myosin heavy chain 7-like
- Symbol
- myh7l Nomenclature History
- Previous Names
-
- myh1 (1)
- vmhcl
- zgc:113832
- zgc:152732
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to myosin complex. Is expressed in adaxial cell; cardiovascular system; and myotome.
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 24 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113832 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Bu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa6839 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa16260 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18394 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19748 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19749 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa39820 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa39821 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
xu093 | Allele with one deletion | Unknown | Unknown | TALEN |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR002928 | Myosin tail |
Domain | IPR004009 | Myosin, N-terminal, SH3-like |
Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
Protein | Length | DNA repair protein XRCC4-like, C-terminal | Kinesin motor domain superfamily | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|
UniProtKB:A7E2H1
|
438 | ||||||
UniProtKB:Q4V9D2
|
638 | ||||||
UniProtKB:A0A8M1NBP6
|
1936 |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-77A20 | ZFIN Curated Data | |
Encodes | cDNA | MGC:113832 | ZFIN Curated Data | |
Encodes | cDNA | MGC:152732 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192541 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001077464 (1) | 6068 nt | ||
Genomic | GenBank:CR925708 (1) | 229824 nt | ||
Polypeptide | UniProtKB:A0A8M1NBP6 (1) | 1936 aa |
No data available
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Kahsay, A., Dennhag, N., Liu, J.X., Nord, H., Rönnbäck, H., Thorell, A.E., von Hofsten, J., Pedrosa Domellöf, F. (2024) Obscurin Maintains Myofiber Identity in Extraocular Muscles. Investigative ophthalmology & visual science. 65:1919
- Zhu, P., Li, J., Yan, F., Islam, S., Lin, X., Xu, X. (2024) Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish. JCI insight. 9(7):
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Singh Angom, R., Wang, Y., Wang, E., Dutta, S., Mukhopadhyay, D. (2023) Conditional, Tissue-Specific CRISPR/Cas9 Vector System in Zebrafish Reveals the Role of Nrp1b in Heart Regeneration. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(10):1921-1934
- El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029
- Hesaraki, M., Bora, U., Pahlavan, S., Salehi, N., Mousavi, S.A., Barekat, M., Rasouli, S.J., Baharvand, H., Ozhan, G., Totonchi, M. (2022) A Novel Missense Variant in Actin Binding Domain of MYH7 Is Associated With Left Ventricular Noncompaction. Frontiers in cardiovascular medicine. 9:839862
- Huang, M., Akerberg, A.A., Zhang, X., Yoon, H., Joshi, S., Hallinan, C., Nguyen, C., Pu, W.T., Haigis, M.C., Burns, C.G., Burns, C.E. (2022) Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nature communications. 13:5877
- Lai, H.H., Yeh, K.Y., Hsu, H.M., Her, G.M. (2022) Deficiency of Adipose Triglyceride Lipase Induces Metabolic Syndrome and Cardiomyopathy in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Zhou, C., Zhao, W., Zhang, S., Ma, J., Sultan, Y., Li, X. (2022) High-throughput transcriptome sequencing reveals the key stages of cardiovascular development in zebrafish embryos. BMC Genomics. 23:587
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