Gene

eif2ak1

ID

ZDB-GENE-061013-268

Name

eukaryotic translation initiation factor 2-alpha kinase 1

Symbol

eif2ak1 Nomenclature History

Previous Names

fj97h09
wu:fj97h09
zgc:153232

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in regulation of translational initiation. Predicted to act upstream of or within protein phosphorylation and translational initiation. Predicted to be active in cytoplasm and nucleus. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eif2ak1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome	618878

Associated With eif2ak1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR054521	Heme-regulated eIF-2-alpha kinase, helical domain
Family	IPR050339	Cell Cycle and Stress Response Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily