Gene

setdb1b

ID

ZDB-GENE-061013-224

Name

SET domain bifurcated histone lysine methyltransferase 1b

Symbol

setdb1b Nomenclature History

Previous Names

im:7143091
wu:fa04a12
wu:fj80h02
zgc:152899

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have histone methyltransferase activity (H3-K9 specific) and promoter-specific chromatin binding activity. Predicted to be involved in Ras protein signal transduction; chromatin organization; and regulation of gene expression. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7143091 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setdb1b Human Ortholog

No data available

Associated With setdb1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001214	SET domain
Domain	IPR001739	Methyl-CpG DNA binding
Domain	IPR002999	Tudor domain
Domain	IPR003616	Post-SET domain
Domain	IPR007728	Pre-SET domain
Domain	IPR040880	Domain of unknown function DUF5604
Domain	IPR041291	Histone methyltransferase, Tudor domain 1
Domain	IPR041292	Histone methyltransferase, Tudor domain 2
Domain	IPR047232	Histone-lysine N-methyltransferase SETDB1/2-like, methyl-CpG binding domains
Family	IPR025796	Histone-lysine N-methyltransferase SETDB1
Family	IPR051516	Histone-lysine N-methyltransferase SETDB
Homologous_superfamily	IPR016177	DNA-binding domain superfamily
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	DNA-binding domain superfamily	Domain of unknown function DUF5604	Histone-lysine N-methyltransferase SETDB	Histone-lysine N-methyltransferase SETDB1	Histone-lysine N-methyltransferase SETDB1/2-like, methyl-CpG binding domains	Histone methyltransferase, Tudor domain 1	Histone methyltransferase, Tudor domain 2	Methyl-CpG DNA binding	Post-SET domain	Pre-SET domain	SET domain	SET domain superfamily	Tudor domain
UniProtKB:Q08BR4 InterPro	1216
UniProtKB:A0A0R4IUW4 InterPro	1242
UniProtKB:A0A8M1NBP0 InterPro	1214
UniProtKB:A0A8M2B4Z0 InterPro	1226

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	setdb1b-202 (1) Ensembl	Ensembl	4,343 nt	Select Tool
mRNA	setdb1b-203 (1) Ensembl	Ensembl	838 nt	Select Tool
mRNA	setdb1b-204 (1) Ensembl	Ensembl	3,729 nt	Select Tool ZFIN BLAST
mRNA	setdb1b-205 (1) Ensembl	Ensembl	732 nt	Select Tool
ncRNA	ottdart00000052496 (1) Ensembl	Ensembl	811 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations