Gene

ccdc86

ID

ZDB-GENE-061009-11

Name

coiled-coil domain containing 86

Symbol

ccdc86 Nomenclature History

Previous Names

im:7155625
si:ch211-217k17.7

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including head; immature eye; mesoderm; midbrain; and neural plate. Orthologous to human CCDC86 (coiled-coil domain containing 86).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7155625 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
zko1033a	Allele with one delins	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
CRISPR1-ccdc86	zko1033a	China Zebrafish Resource Center (CZRC)

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Human Disease

Associated With ccdc86 Human Ortholog

No data available

Associated With ccdc86 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR005579	Cgr1-like
Family	IPR026570	Coiled-coil domain-containing protein 86

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Domain Details Per Protein

Protein	Length	Cgr1-like	Coiled-coil domain-containing protein 86
UniProtKB:A2BG55 InterPro	283

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 1

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:ch211-217k17.7-201 (1) Ensembl	Ensembl		1,212 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-217K17	BX323839	ZFIN Curated Data
Encodes	EST	IMAGE:7155625	CK691627	Thisse et al., 2004

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001145359 (1)	1212 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX323839 (1)	155358 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A2BG55 (1)	283 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	CCDC86	11	Ensembl:ENSG00000110104 Gene:79080 OMIM:611293 HGNC:28359	Phylogenetic tree (1) Amino acid sequence comparison (1)
Mouse	Ccdc86	19	Ensembl:ENSMUSG00000024732 MGI:1277220 Gene:108673	Amino acid sequence comparison (1) Phylogenetic tree (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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