Gene
mark3b
- ID
- ZDB-GENE-060929-80
- Name
- MAP/microtubule affinity-regulating kinase 3b
- Symbol
- mark3b Nomenclature History
- Previous Names
-
- si:dkeyp-50f7.6
- zgc:153725
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| visual impairment and progressive phthisis bulbi | Alliance | ?Visual impairment and progressive phthisis bulbi | 618283 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001772 | Kinase associated domain 1 (KA1) |
| Domain | IPR015940 | Ubiquitin-associated domain |
| Domain | IPR049508 | Serine/threonine-protein kinase MARK 1-4, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028375 | KA1 domain/Ssp2, C-terminal |
Domain Details Per Protein
| Protein | Length | KA1 domain/Ssp2, C-terminal | Kinase associated domain 1 (KA1) | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase MARK 1-4, catalytic domain | Ubiquitin-associated domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AL25
|
834 | ||||||||
|
UniProtKB:A0A8M3B4C1
|
825 | ||||||||
|
UniProtKB:A2CEF7
|
754 | ||||||||
|
UniProtKB:A0A8M3ALR5
|
814 | ||||||||
|
UniProtKB:A0A8M2BHK1
|
765 | ||||||||
|
UniProtKB:A0A8M2BHK8
|
774 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mark3b-201
(1)
|
Ensembl | 4,411 nt | ||
| mRNA |
mark3b-203
(1)
|
Ensembl | 640 nt | ||
| ncRNA |
mark3b-002
(1)
|
Ensembl | 1,263 nt |
Interactions and Pathways
No data available
Plasmids
No data available