Gene

vps4a

ID

ZDB-GENE-060929-388

Name

vacuolar protein sorting 4 homolog A

Symbol

vps4a Nomenclature History

Previous Names

zgc:153907

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity. Predicted to be involved in endosomal transport and vacuole organization. Predicted to act upstream of or within cell division. Predicted to be located in late endosome membrane. Orthologous to human VPS4A (vacuolar protein sorting 4 homolog A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vps4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		CIMDAG syndrome	619273

Associated With vps4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR007330	MIT domain
Domain	IPR015415	Spastin/Vps4, C-terminal
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Domain	IPR045253	Vacuolar protein sorting-associated protein 4, MIT domain
Family	IPR050304	Microtubule-severing AAA ATPase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036181	MIT domain superfamily

Domain Details Per Protein

Protein	Length	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	Microtubule-severing AAA ATPase	MIT domain	MIT domain superfamily	P-loop containing nucleoside triphosphate hydrolase	Spastin/Vps4, C-terminal	Vacuolar protein sorting-associated protein 4, MIT domain
UniProtKB:Q08BZ6 InterPro	440
UniProtKB:A0A8M3AP98 InterPro	436

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	vps4a-201 (1) Ensembl	Ensembl		1,508 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations