Gene

eml1

ID

ZDB-GENE-060929-156

Name

EMAP like 1

Symbol

eml1 Nomenclature History

Previous Names

eml1a (1)
CNG-modulin (1)
wu:fj01a06
zgc:153105

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have microtubule binding activity. Involved in cone photoresponse recovery. Predicted to colocalize with mitotic spindle. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Is expressed in anterior macula; eye; and retinal cone cell. Orthologous to human EML1 (EMAP like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Korenbrot et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eml1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
subcortical band heterotopia	Alliance	Band heterotopia	600348

Associated With eml1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR005108	HELP motif
Family	IPR050630	WD repeat Echinoderm Microtubule-associated Protein-like
Homologous_superfamily	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	HELP motif	Quinoprotein alcohol dehydrogenase-like superfamily	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily	WD repeat Echinoderm Microtubule-associated Protein-like
UniProtKB:A0A8M2B5R3 InterPro	822
UniProtKB:A0A8M9P921 InterPro	839
UniProtKB:A0A8M9PED7 InterPro	835
UniProtKB:E7EXY5 InterPro	813
UniProtKB:A0A2R8RMY7 InterPro	817
UniProtKB:A0A8M9P088 InterPro	840
UniProtKB:A0A8M9PKW5 InterPro	827
UniProtKB:A0A8M9PNX0 InterPro	831

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	eml1-201 (1) Ensembl	Ensembl	1,528 nt	Select Tool
mRNA	eml1-202 (1) Ensembl	Ensembl	3,487 nt	Select Tool
mRNA	eml1-203 (1) Ensembl	Ensembl	539 nt	Select Tool
mRNA	eml1-206 (1) Ensembl	Ensembl	515 nt	Select Tool
mRNA	eml1-207 (1) Ensembl	Ensembl	6,463 nt	Select Tool ZFIN BLAST
mRNA	eml1-208 (1) Ensembl	Ensembl	6,037 nt	Select Tool ZFIN BLAST
mRNA	eml1-209 (1) Ensembl	Ensembl	6,445 nt	Select Tool ZFIN BLAST
mRNA	eml1-210 (1) Ensembl	Ensembl	6,472 nt	Select Tool ZFIN BLAST
ncRNA	eml1-004 (1) Ensembl	Ensembl	653 nt	Select Tool
ncRNA	eml1-005 (1) Ensembl	Ensembl	510 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-eml1	polyclonal	eml1		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations