Gene
exoc6b
- ID
- ZDB-GENE-060929-132
- Name
- exocyst complex component 6B
- Symbol
- exoc6b Nomenclature History
- Previous Names
-
- fa55b02
- wu:fa55b02
- zgc:153610
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to act upstream of or within intracellular protein transport. Predicted to be part of exocyst. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to human EXOC6B (exocyst complex component 6B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029306Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20933 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34065 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34066 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40885 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40886 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepimetaphyseal dysplasia with joint laxity type 3 | Alliance | Spondyloepimetaphyseal dysplasia with joint laxity, type 3 | 618395 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR046361 | Exocyst complex subunit EXOC6/Sec15, C-terminal |
| Domain | IPR048359 | Exocyst complex component EXOC6/Sec15, N-terminal domain |
| Family | IPR007225 | Exocyst complex component EXOC6/Sec15 |
| Homologous_superfamily | IPR042044 | EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 |
| Homologous_superfamily | IPR042045 | Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 |
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Domain Details Per Protein
| Protein | Length | EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 | Exocyst complex component EXOC6/Sec15 | Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 | Exocyst complex component EXOC6/Sec15, N-terminal domain | Exocyst complex subunit EXOC6/Sec15, C-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q814
|
816 | |||||
|
UniProtKB:A0A8M3AU30
|
806 | |||||
|
UniProtKB:A0A0R4ILM6
|
802 | |||||
|
UniProtKB:A0A8M9QH78
|
812 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
exoc6b-201
(1)
|
Ensembl | 4,170 nt | ||
| mRNA |
exoc6b-202
(1)
|
Ensembl | 735 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-319E19 | ZFIN Curated Data | |
| Contained in | BAC | CH73-368P22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-23I12 | ZFIN Curated Data | |
| Encodes | EST | fa55b02 | ||
| Encodes | cDNA | MGC:153610 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001076730 (1) | 4102 nt | ||
| Genomic | GenBank:AL954715 (1) | 195884 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q814 (1) | 816 aa |
- Rodríguez-Marí, A., Cañestro, C., Bremiller, R.A., Catchen, J.M., Yan, Y.L., and Postlethwait, J.H. (2013) Retinoic Acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish. PLoS One. 8(9):e73951
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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