Gene
ears2
- ID
- ZDB-GENE-060825-214
- Name
- glutamyl-tRNA synthetase 2, mitochondrial
- Symbol
- ears2 Nomenclature History
- Previous Names
-
- zgc:153247
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have glutamate-tRNA ligase activity. Predicted to be involved in glutamyl-tRNA aminoacylation. Predicted to localize to mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 12 | Alliance | Combined oxidative phosphorylation deficiency 12 | 614924 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR020058 | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain |
| Domain | IPR033910 | Glutamyl-tRNA synthetase |
| Domain | IPR045462 | Aminoacyl-tRNA synthetase, class I, anticodon-binding |
| Family | IPR000924 | Glutamyl/glutaminyl-tRNA synthetase |
| Family | IPR004527 | Glutamate-tRNA ligase, bacterial/mitochondrial |
| Family | IPR049940 | Glutamyl-Q tRNA(Asp) synthetase/Glutamate--tRNA ligase |
| Homologous_superfamily | IPR008925 | Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR020751 | Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class I, anticodon-binding | Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 | Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily | Aminoacyl-tRNA synthetase, class I, conserved site | Glutamate-tRNA ligase, bacterial/mitochondrial | Glutamyl/glutaminyl-tRNA synthetase | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain | Glutamyl-Q tRNA(Asp) synthetase/Glutamate--tRNA ligase | Glutamyl-tRNA synthetase | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q7R8
|
524 | ||||||||||
|
UniProtKB:Q0P499
|
503 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available