Gene
gck
- ID
- ZDB-GENE-060825-204
- Name
- glucokinase (hexokinase 4)
- Symbol
- gck Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have fructokinase activity; glucokinase activity; and mannokinase activity. Involved in glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Is expressed in brain; digestive system; female organism; heart; and muscle. Orthologous to human GCK (glucokinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hyperinsulinemic hypoglycemia 3 | Alliance | Hyperinsulinemic hypoglycemia, familial, 3 | 602485 |
| maturity-onset diabetes of the young type 2 | Alliance | MODY, type II | 125851 |
| permanent neonatal diabetes mellitus | Alliance | Diabetes mellitus, permanent neonatal 1 | 606176 |
| type 2 diabetes mellitus | Alliance | Diabetes mellitus, noninsulin-dependent, late onset | 125853 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ATPase, nucleotide binding domain | Hexokinase | Hexokinase, binding site | Hexokinase, C-terminal | Hexokinase, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:F1RC38
|
476 |
Interactions and Pathways
No data available
Plasmids
No data available