Gene

ptbp2b

ID

ZDB-GENE-060810-49

Name

polypyrimidine tract binding protein 2b

Symbol

ptbp2b Nomenclature History

Previous Names

ptbp2
im:7153495
si:ch211-160l17.2
wu:fa08f05
wu:fc05d10

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have mRNA binding activity. Predicted to be involved in negative regulation of RNA splicing and regulation of translation. Predicted to localize to nucleus. Is expressed in central nervous system; cranial ganglion; retinal ganglion cell layer; and retinal inner nuclear layer. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7153495 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptbp2b Human Ortholog

No data available

Associated With ptbp2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR021790	PTBP1-like, RNA recognition motif 2
Domain	IPR035002	PTBP2, RNA recognition motif 1
Family	IPR006536	HnRNP-L/PTB
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	HnRNP-L/PTB	Nucleotide-binding alpha-beta plait domain superfamily	PTBP1-like, RNA recognition motif 2	PTBP2, RNA recognition motif 1	RNA-binding domain superfamily	RNA recognition motif domain
UniProtKB:A0A8M2BAH6 InterPro	518
UniProtKB:A5PM68 InterPro	538

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	ptbp2b-203 (1) Ensembl	Ensembl	759 nt	Select Tool
mRNA	ptbp2b-201 (1) Ensembl	Ensembl	2,900 nt	Select Tool
mRNA	ptbp2b-204 (1) Ensembl	Ensembl	281 nt	Select Tool
ncRNA	ptbp2b-003 (1) Ensembl	Ensembl	518 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations