Gene
mlh3
- ID
- ZDB-GENE-060810-45
- Name
- mutL homolog 3 (E. coli)
- Symbol
- mlh3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152582 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| endometrial cancer | Alliance | {Endometrial cancer, susceptibility to} | 608089 |
| hereditary nonpolyposis colorectal cancer type 7 | Alliance | Colorectal cancer, hereditary nonpolyposis, type 7 | 614385 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013507 | DNA mismatch repair protein, S5 domain 2-like |
| Domain | IPR014790 | MutL, C-terminal, dimerisation |
| Family | IPR002099 | DNA mismatch repair protein MutL/Mlh/PMS |
| Family | IPR038973 | DNA mismatch repair protein MutL/Mlh/Pms-like |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| Homologous_superfamily | IPR037198 | MutL, C-terminal domain superfamily |
| Homologous_superfamily | IPR042120 | MutL, C-terminal domain, dimerisation subdomain |
| Homologous_superfamily | IPR042121 | MutL, C-terminal domain, regulatory subdomain |
Domain Details Per Protein
| Protein | Length | DNA mismatch repair protein MutL/Mlh/PMS | DNA mismatch repair protein MutL/Mlh/Pms-like | DNA mismatch repair protein, S5 domain 2-like | Histidine kinase/HSP90-like ATPase superfamily | MutL, C-terminal, dimerisation | MutL, C-terminal domain, dimerisation subdomain | MutL, C-terminal domain, regulatory subdomain | MutL, C-terminal domain superfamily | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T846
|
1043 | ||||||||||
|
UniProtKB:A0A8M2B931
|
1144 | ||||||||||
|
UniProtKB:A0A8M9PFG3
|
1043 | ||||||||||
|
UniProtKB:A0A8M9P5H1
|
1144 |
Interactions and Pathways
No data available
Plasmids
No data available