Gene
zranb3
- ID
- ZDB-GENE-060712-1
- Name
- zinc finger, RAN-binding domain containing 3
- Symbol
- zranb3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA endonuclease activity. Acts upstream of or within regulation of type B pancreatic cell apoptotic process. Predicted to be active in nuclear replication fork. Orthologous to human ZRANB3 (zinc finger RANBP2-type containing 3).
- Genome Resources
- Note
-
ENSDARG00000091538 is also part of this gene
- Comparative Information
-
- All Expression Data
- 1 figure from Adeyemo et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Adeyemo et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24102 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37453 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37454 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45757 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3229 | Allele with one deletion | Exon 4 | Frameshift | CRISPR | |
| zf3230 | Allele with one deletion | Exon 4 | Frameshift | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zranb3 | Adeyemo et al., 2019 | |
| CRISPR2-zranb3 | Adeyemo et al., 2019 | |
| CRISPR3-zranb3 | Shin et al., 2021 | |
| MO1-zranb3 | N/A | Huang et al., 2013 |
| MO2-zranb3 | N/A | Huang et al., 2013 |
| MO3-zranb3 | N/A | Adeyemo et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | HNH endonuclease | HNH nuclease | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7EXE0 | InterPro | 1112 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zranb3-201
(1)
|
Ensembl | 5,016 nt | ||
| mRNA |
zranb3-202
(1)
|
Ensembl | 792 nt | ||
| mRNA |
zranb3-203
(1)
|
Ensembl | 5,140 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-109O7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017353438 (1) | 3501 nt | ||
| Genomic | GenBank:LO018199 (1) | 38384 nt | ||
| Polypeptide | UniProtKB:E7EXE0 (1) | 1112 aa |
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Adeyemo, A.A., Zaghloul, N.A., Chen, G., Doumatey, A.P., Leitch, C.C., Hostelley, T.L., Nesmith, J.E., Zhou, J., Bentley, A.R., Shriner, D., Fasanmade, O., Okafor, G., Eghan, B., Agyenim-Boateng, K., Chandrasekharappa, S., Adeleye, J., Balogun, W., Owusu, S., Amoah, A., Acheampong, J., Johnson, T., Oli, J., Adebamowo, C., South Africa Zulu Type 2 Diabetes Case-Control Study, Collins, F., Dunston, G., Rotimi, C.N. (2019) ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response. Nature communications. 10:3195
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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