ZFIN is now using GRCz12tu for Genomic Data
Gene
tbc1d1
- ID
- ZDB-GENE-060710-1
- Name
- TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
- Symbol
- tbc1d1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Orthologous to human TBC1D1 (TBC1 domain family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028099Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028100Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8796 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18692 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32641 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32642 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32643 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zko353a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko353b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Domain of unknown function DUF3350 | PH-like domain superfamily | PTB/PI domain | Rab-GAP-TBC domain | Rab-GAP-TBC domain superfamily | Rab GTPase-activating TBC domain-containing protein |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7UT15 | InterPro | 1203 | ||||||
| UniProtKB:A0A8M9QE63 | InterPro | 1236 | ||||||
| UniProtKB:A0A8M2BFN8 | InterPro | 1276 | ||||||
| UniProtKB:A0A8M9Q8V8 | InterPro | 1115 | ||||||
| UniProtKB:A0A8M2BGB4 | InterPro | 1130 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tbc1d1-201
(1)
|
Ensembl | 5,011 nt | ||
| mRNA |
tbc1d1-204
(1)
|
Ensembl | 4,891 nt | ||
| mRNA |
tbc1d1-205
(1)
|
Ensembl | 4,792 nt | ||
| mRNA |
tbc1d1-206
(1)
|
Ensembl | 6,261 nt | ||
| mRNA |
tbc1d1-207
(1)
|
Ensembl | 3,555 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-285M21 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073950094 (1) | GRCz12tu | 4342 nt | |
| Genomic | GenBank:BX323883 (1) | 195250 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFN8 (1) | 1276 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | TBC1D1 | 4 | Amino acid sequence comparison (1) |
- Cao, B., Zhou, J., Xia, B., Li, X., Wang, R., Xu, Y., Li, C. (2025) Therapeutic potential of a choline-zinc-vitamin E nutraceutical complex in ameliorating thioacetamide-induced nonalcoholic fatty liver pathology in zebrafish. PLoS One. 20:e0324164e0324164
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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