Gene
tbc1d1
- ID
- ZDB-GENE-060710-1
- Name
- TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
- Symbol
- tbc1d1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in cellular response to insulin stimulus. Predicted to be located in cytoplasm. Orthologous to human TBC1D1 (TBC1 domain family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la028099Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028100Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa8796 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18692 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32641 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32642 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32643 | Allele with one point mutation | Unknown | Splice Site | ENU | |
zko353a | Allele with one deletion | Unknown | Unknown | CRISPR | |
zko353b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Domain of unknown function DUF3350 | PH-like domain superfamily | PTB/PI domain | Rab-GAP-TBC domain | Rab-GAP-TBC domain superfamily | Rab GTPase-activating TBC domain-containing protein |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8N7UT15 | InterPro | 1203 | ||||||
UniProtKB:A0A8M9QE63 | InterPro | 1236 | ||||||
UniProtKB:A0A8M2BFN8 | InterPro | 1276 | ||||||
UniProtKB:A0A8M9Q8V8 | InterPro | 1115 | ||||||
UniProtKB:A0A8M2BGB4 | InterPro | 1130 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
tbc1d1-201
(1)
|
Ensembl | 5,011 nt | ||
mRNA |
tbc1d1-204
(1)
|
Ensembl | 4,891 nt | ||
mRNA |
tbc1d1-205
(1)
|
Ensembl | 4,792 nt | ||
mRNA |
tbc1d1-206
(1)
|
Ensembl | 6,261 nt | ||
mRNA |
tbc1d1-207
(1)
|
Ensembl | 3,555 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-285M21 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_021476243 (1) | 5230 nt | ||
Genomic | GenBank:BX323883 (1) | 195250 nt | ||
Polypeptide | UniProtKB:A0A8M2BFN8 (1) | 1276 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | TBC1D1 | 4 | Amino acid sequence comparison (1) |
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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