Gene
topbp1
- ID
- ZDB-GENE-060626-1
- Name
- DNA topoisomerase II binding protein 1
- Symbol
- topbp1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Involved in cellular response to DNA damage stimulus; definitive hemopoiesis; and regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Localizes to nucleus. Is expressed in caudal fin and head. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gao et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gao et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | BRCT domain | BRCT domain superfamily | DNA topoisomerase 2-binding protein 1, eighth BRCT domain | DNA topoisomerase 2-binding protein 1-like, BRCT0 domain | TopBP1, first BRCT domain |
|---|---|---|---|---|---|---|
|
UniProtKB:F1R135
|
1520 | |||||
|
UniProtKB:A0A2R8RVN3
|
1526 | |||||
|
UniProtKB:A0A8M6YVL2
|
1519 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
topbp1-201
(1)
|
Ensembl | 7,055 nt | ||
| mRNA |
topbp1-202
(1)
|
Ensembl | 4,697 nt | ||
| mRNA |
topbp1-203
(1)
|
Ensembl | 4,691 nt |
Interactions and Pathways
No data available
Plasmids
No data available