Gene

itgav

ID

ZDB-GENE-060616-382

Name

integrin, alpha V

Symbol

itgav Nomenclature History

Previous Names

zgc:136222 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable integrin binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; axis elongation involved in somitogenesis; and endothelial cell proliferation. Part of integrin complex. Is expressed in several structures, including axis; cardiovascular system; diencephalon; head; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itgav Human Ortholog

No data available

Associated With itgav Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain	IPR013649	Integrin alpha, first immunoglubulin-like domain
Domain	IPR048285	Integrin alpha, second immunoglobulin-like domain
Domain	IPR048286	Integrin alpha, third immunoglobulin-like domain
Family	IPR000413	Integrin alpha chain
Homologous_superfamily	IPR028994	Integrin alpha, N-terminal
Homologous_superfamily	IPR032695	Integrin domain superfamily
Repeat	IPR013517	FG-GAP repeat
Repeat	IPR013519	Integrin alpha beta-propellor