Gene
top1a
- ID
- ZDB-GENE-060616-217
- Name
- DNA topoisomerase Ia
- Symbol
- top1a Nomenclature History
- Previous Names
-
- top1l
- wu:fc66a02
- zgc:136349
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Predicted to act upstream of or within rhythmic process. Predicted to be located in chromosome and nucleus. Predicted to be active in nucleolus. Orthologous to human TOP1 (DNA topoisomerase I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898978 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| DNA topoisomerase I, camptothecin-resistant |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018521 | DNA topoisomerase I, active site |
| Domain | IPR008336 | DNA topoisomerase I, DNA binding, eukaryotic-type |
| Domain | IPR013499 | DNA topoisomerase I, eukaryotic-type |
| Domain | IPR013500 | DNA topoisomerase I, catalytic core, eukaryotic-type |
| Domain | IPR025834 | Topoisomerase I C-terminal domain |
| Domain | IPR048045 | DNA topoisomerase I, DNA-binding domain |
| Family | IPR001631 | DNA topoisomerase I |
| Family | IPR051062 | DNA topoisomerase IB |
| Homologous_superfamily | IPR011010 | DNA breaking-rejoining enzyme, catalytic core |
| Homologous_superfamily | IPR013030 | DNA topoisomerase I, DNA binding, N-terminal domain 2 |
| Homologous_superfamily | IPR013034 | DNA topoisomerase I, DNA binding, N-terminal domain 1 |
| Homologous_superfamily | IPR014711 | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type |
| Homologous_superfamily | IPR014727 | DNA topoisomerase I, catalytic core, alpha/beta subdomain |
| Homologous_superfamily | IPR036202 | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA breaking-rejoining enzyme, catalytic core | DNA topoisomerase I | DNA topoisomerase I, active site | DNA topoisomerase IB | DNA topoisomerase I, catalytic core, alpha/beta subdomain | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type | DNA topoisomerase I, catalytic core, eukaryotic-type | DNA topoisomerase I, DNA-binding domain | DNA topoisomerase I, DNA binding, eukaryotic-type | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA topoisomerase I, eukaryotic-type | Topoisomerase I C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1ED17
|
758 |
Interactions and Pathways
No data available
Plasmids
No data available