Gene
thrab
- ID
- ZDB-GENE-060613-1
- Name
- thyroid hormone receptor alpha b
- Symbol
- thrab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of or within heart development and positive regulation of sarcomere organization. Predicted to be located in nucleus. Is expressed in several structures, including blastodisc; cardiovascular system; mandibular arch skeleton; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (thyroid hormone receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017632 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nongoitrous hypothyroidism 6 | Alliance | Hypothyroidism, congenital, nongoitrous, 6 | 614450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR001728 | Thyroid hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:U3JAT9
|
409 | |||||||
|
UniProtKB:A0A8M3B4P5
|
419 | |||||||
|
UniProtKB:A0A8M3AYH1
|
411 |
Interactions and Pathways
No data available
Plasmids
No data available