Gene
slc8a2a
- ID
- ZDB-GENE-060531-155
- Name
- solute carrier family 8 member 2a
- Symbol
- slc8a2a Nomenclature History
- Previous Names
-
- ncx2a (1)
- si:dkey-85k8.4
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to act upstream of or within cell communication; metal ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in ovary. Orthologous to human SLC8A2 (solute carrier family 8 member A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Liao et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR004837 | Sodium/calcium exchanger membrane region |
| Domain | IPR032452 | Sodium/calcium exchanger domain, C-terminal extension |
| Family | IPR004836 | Sodium/calcium exchanger protein |
| Family | IPR051171 | Calcium/Cation Antiporter |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Homologous_superfamily | IPR044880 | NCX, central ion-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium/Cation Antiporter | CalX-like domain superfamily | Na-Ca exchanger/integrin-beta4 | NCX, central ion-binding domain superfamily | Sodium/calcium exchanger domain, C-terminal extension | Sodium/calcium exchanger membrane region | Sodium/calcium exchanger protein |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASJ4 | InterPro | 919 | |||||||
| UniProtKB:A0A8M3ASJ9 | InterPro | 682 | |||||||
| UniProtKB:A0A286Y8H6 | InterPro | 891 | |||||||
| UniProtKB:A0A8M3B9T8 | InterPro | 913 | |||||||
| UniProtKB:A0A8M3AZU6 | InterPro | 857 | |||||||
| UniProtKB:B2CZC3 | InterPro | 891 | |||||||
| UniProtKB:A0A8M3ASN9 | InterPro | 897 | |||||||
| UniProtKB:A0A8M3B9U2 | InterPro | 676 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc8a2a-201
(1)
|
Ensembl | 2,685 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-85K8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123296 (1) | 3314 nt | ||
| Genomic | GenBank:BX547938 (1) | 162785 nt | ||
| Polypeptide | UniProtKB:A0A8M3ASJ4 (1) | 919 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Barat, A., Sahoo, P.K., Kumar, R., Pande, V. (2016) Solute Carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 200:54-61
- Orosz, F. (2015) On the tubulin polymerization promoting proteins of zebrafish. Biochemical and Biophysical Research Communications. 457(3):267-72
- Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9
- Cambier, S., Gonzalez, P., Mesmer-Dudons, N., Brèthes, D., Fujimura, M., and Bourdineaud, J.P. (2012) Effects of dietary methylmercury on the zebrafish brain: histological, mitochondrial, and gene transcription analyses. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 25(1):165-180
- Liao, B.K., Deng, A.N., Chen, S.C., Chou, M.Y., and Hwang, P.P. (2007) Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. BMC Genomics. 8(1):354
- Marshall, C.R., Fox, J.A., Butland, S.L., Ouellette, B.F., Brinkman, F.S., and Tibbits, G.F. (2005) Phylogeny of Na+-Ca2+ Exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species. Physiological Genomics. 21(2):161-173
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