Gene
cxcl11.8
- ID
- ZDB-GENE-060526-319
- Name
- chemokine (C-X-C motif) ligand 11, duplicate 8
- Symbol
- cxcl11.8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable chemokine activity. Acts upstream of or within response to lipopolysaccharide. Predicted to be located in extracellular space. Is expressed in several structures, including eye; heart; hindbrain; integument; and liver. Orthologous to human CXCL11 (C-X-C motif chemokine ligand 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily | CXC chemokine | CXC Chemokine domain |
|---|---|---|---|---|---|---|
| UniProtKB:A2BHJ6 | InterPro | 102 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcl11.8-201
(1)
|
Ensembl | 780 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-58F10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-97J15 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126413 (1) | 780 nt | ||
| Genomic | GenBank:BX640512 (1) | 191256 nt | ||
| Polypeptide | UniProtKB:A2BHJ6 (1) | 102 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CXCL11 | 4 | Conserved genome location (synteny) (1) |
- Blaser, B.W., Moore, J.L., Hagedorn, E.J., Li, B., Riquelme, R., Lichtig, A., Yang, S., Zhou, Y., Tamplin, O.J., Binder, V., Zon, L.I. (2017) CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. The Journal of experimental medicine. 214(4):1011
- Yoon, S., Alnabulsi, A., Wang, T.Y., Lee, P.T., Chen, T.Y., Bird, S., Zou, J., Secombes, C.J. (2016) Analysis of interferon gamma protein expression in zebrafish (Danio rerio). Fish & shellfish immunology. 57:79-86
- Torraca, V., Cui, C., Boland, R., Bebelman, J.P., van der Sar, A.M., Smit, M.J., Siderius, M., Spaink, H.P., Meijer, A.H. (2015) The CXCR3/CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease models & mechanisms. 8(3):253-69
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Nomiyama, H., Osada, N., and Yoshie, O. (2013) Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history. Genes to cells : devoted to molecular & cellular mechanisms. 18(1):1-16
- van der Aa, L.M., Chadzinska, M., Derks, W., Scheer, M., Levraud, J.P., Boudinot, P., and Lidy Verburg-van Kemenade, B.M. (2012) Diversification of IFNγ-inducible CXCb chemokines in cyprinid fish. Developmental and comparative immunology. 38(2):243-253
- Chen, L.C., Wu, J.L., Shiau, C.Y., and Chen, J.Y. (2010) Organization and promoter analysis of the zebrafish (Danio rerio) chemokine gene (CXC-64) promoter. Fish physiology and biochemistry. 36(3):511-521
- Chen, L.C., Chen, J.Y., Hour, A.L., Shiau, C.Y., Hui, C.F., and Wu, J.L. (2008) Molecular cloning and functional analysis of zebrafish (Danio rerio) chemokine genes. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 151(4):400-409
- Nomiyama, H., Hieshima, K., Osada, N., Kato-Unoki, Y., Otsuka-Ono, K., Takegawa, S., Izawa, T., Yoshizawa, A., Kikuchi, Y., Tanase, S., Miura, R., Kusuda, J., Nakao, M., and Yoshie, O. (2008) Extensive Expansion and Diversification of the Chemokine Gene Family in Zebrafish: Identification of a Novel Chemokine Subfamily CX. BMC Genomics. 9(1):222
- Devries, M.E., Kelvin, A.A., Xu, L., Ran, L., Robinson, J., and Kelvin, D.J. (2006) Defining the origins and evolution of the chemokine/chemokine receptor system. Journal of immunology (Baltimore, Md. : 1950). 176(1):401-415
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