Gene
fer
- ID
- ZDB-GENE-060526-234
- Name
- fer (fps/fes related) tyrosine kinase
- Symbol
- fer Nomenclature History
- Previous Names
-
- si:dkey-190c14.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine kinase activity. Acts upstream of or within blood vessel development and convergent extension involved in gastrulation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in plasma membrane. Is expressed in brain; head; intermediate cell mass of mesoderm; and pectoral fin. Orthologous to human FER (FER tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17460 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fer | N/A | Paardekooper Overman et al., 2014 |
| MO2-fer | N/A | Paardekooper Overman et al., 2014 |
| MO3-fer | N/A | Dunn et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001060 | FCH domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR031160 | F-BAR domain |
| Domain | IPR035849 | Fes/Fps/Fer, SH2 domain |
| Domain | IPR037452 | Tyrosine-protein kinase Fer, F-BAR domain |
| Family | IPR016250 | Tyrosine-protein kinase, Fes/Fps type |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Fes/Fps/Fer, SH2 domain | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase Fer, F-BAR domain | Tyrosine-protein kinase, Fes/Fps type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q1U2 | InterPro | 822 | |||||||||||||||
| UniProtKB:A0A8M3ASR9 | InterPro | 827 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-64E1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-190C14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_688484 (1) | 5298 nt | ||
| Genomic | GenBank:CR759821 (1) | 169089 nt | ||
| Polypeptide | UniProtKB:A0A8M3ASR9 (1) | 827 aa |
- Dunn, E.M., Billquist, E.J., VanderStoep, A.L., Bax, P.G., Westrate, L.M., McLellan, L.K., Peterson, S.C., MacKeigan, J.P., Putzke, A.P. (2017) Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development. Biology. 6(4)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Paardekooper Overman, J., Preisinger, C., Prummel, K., Bonetti, M., Giansanti, P., Heck, A., Hertog, J.D. (2014) Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome. PLoS One. 9:e106682
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