pdk4

ID

ZDB-GENE-060503-754

Name

pyruvate dehydrogenase kinase, isozyme 4

Symbol

pdk4 Nomenclature History

Previous Names

si:rp71-57j15.4

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in insulin receptor signaling pathway; regulation of glucose metabolic process; and regulation of pyruvate decarboxylation to acetyl-CoA. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in cardiac ventricle. Orthologous to several human genes including PDK2 (pyruvate dehydrogenase kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pdk4 Human Ortholog

No data available

Associated With pdk4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003594	Histidine kinase/HSP90-like ATPase domain
Domain	IPR005467	Histidine kinase domain
Domain	IPR018955	Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
Family	IPR039028	PDK/BCKDK protein kinase
Homologous_superfamily	IPR036784	Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
Homologous_superfamily	IPR036890	Histidine kinase/HSP90-like ATPase superfamily