Gene

rspo2

ID

ZDB-GENE-060503-667

Name

R-spondin 2

Symbol

rspo2 Nomenclature History

Previous Names

si:ch211-149p10.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable heparin binding activity. Acts upstream of or within several processes, including cranial skeletal system development; fin development; and regulation of odontogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including brain; cranium; fin; forebrain midbrain boundary neural rod; and inner dental epithelium. Human ortholog(s) of this gene implicated in tetraamelia syndrome 2. Orthologous to human RSPO2 (R-spondin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rspo2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
tetraamelia syndrome 2	Alliance	Tetraamelia syndrome 2	618021
		?Humerofemoral hypoplasia with radiotibial ray deficiency	618022

Associated With rspo2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR043601	R-spondin, Fu-CRD domain
Domain	IPR044004	Spondin-like TSP1 domain
Family	IPR051514	R-spondin domain-containing protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR006212	Furin-like repeat