Gene

scn1ba

ID

ZDB-GENE-060503-604

Name

sodium channel, voltage-gated, type I, beta a

Symbol

scn1ba Nomenclature History

Previous Names

scn1b
si:ch211-265p12.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Contributes to voltage-gated sodium channel activity. Involved in sodium ion transport. Predicted to localize to voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 5; early infantile epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Is expressed in gill; heart; liver; musculature system; and nervous system. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scn1ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Brugada syndrome 5	Alliance	Brugada syndrome 5	612838
Brugada syndrome 5	Alliance	Cardiac conduction defect, nonspecific	612838
developmental and epileptic encephalopathy 52	Alliance	Developmental and epileptic encephalopathy 52	617350
familial atrial fibrillation	Alliance	Atrial fibrillation, familial, 13	615377
generalized epilepsy with febrile seizures plus 1	Alliance	Generalized epilepsy with febrile seizures plus, type 1	604233

Associated With scn1ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Family	IPR027098	Sodium channel subunit beta-1/beta-3
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin V-set domain	Sodium channel subunit beta-1/beta-3
UniProtKB:Q06W32 InterPro	221
UniProtKB:A0A8M2B4J3 InterPro	173
UniProtKB:Q06W35 InterPro	209

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	scn1ba-201 (1) Ensembl	Havana	1414 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	scn1ba-202 (1) Ensembl	Havana	1446 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	scn1ba-203 (1) Ensembl	Havana	1051 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	scn1ba-003 (1) Ensembl	Havana	598 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations