Gene
slc26a4
- ID
- ZDB-GENE-060503-544
- Name
- solute carrier family 26 member 4
- Symbol
- slc26a4 Nomenclature History
- Previous Names
-
- si:dkey-31f5.9
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Acts upstream of or within chloride transport; monoatomic anion homeostasis; and response to salt stress. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including gill; heart; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Orthologous to human SLC26A4 (solute carrier family 26 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20257 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc26a4 | (3) | |
| CRISPR2-slc26a4 | (2) | |
| MO1-slc26a4 | N/A | Bayaa et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 4 | Alliance | Deafness, autosomal recessive 4, with enlarged vestibular aqueduct | 600791 |
| Pendred Syndrome | Alliance | Pendred syndrome | 274600 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SLC26A/SulP transporter | SLC26A/SulP transporter domain | STAS domain | STAS domain superfamily | Sulphate anion transporter, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z5Y9 | InterPro | 779 | |||||
| UniProtKB:C8XTB7 | InterPro | 760 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc26a4-201
(1)
|
Ensembl | 2,280 nt | ||
| mRNA |
slc26a4-202
(1)
|
Ensembl | 2,232 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31F5 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-15G12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001165915 (1) | 2390 nt | ||
| Genomic | GenBank:BX649534 (1) | 205347 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z5Y9 (1) | 779 aa |
- Abu Obaid, A., Ivandic, I., Korsching, S.I. (2024) Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis. Cellular and molecular life sciences : CMLS. 81:213213
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Carrington, B., Varshney, G.K., Burgess, S.M., Sood, R. (2015) CRISPR-STAT: an easy and reliable PCR-based method to evaluate target-specific sgRNA activity. Nucleic acids research. 43(22):e157
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, F., Xia, W., Hu, J., Wang, Y., Yang, F., Sun, S., Zhang, J., Jiang, N., Wang, H., Tian, W., Wang, X., Ma, D. (2015) Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. PLoS One. 10:e0136832
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Bayaa, M., Vulesevic, B., Esbaugh, A., Braun, M., Ekker, M.E., Grosell, M., and Perry, S.F. (2009) The involvement of SLC26 anion transporters in chloride uptake in zebrafish (Danio rerio) larvae. The Journal of experimental biology. 212(Pt 20):3283-3295
- Perry, S.F., Vulesevic, B., Grosell, M., and Bayaa, M. (2009) Evidence that SLC26 anion transporters mediate branchial chloride uptake in adult zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 297(4):R988-R997
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