Gene

vps45

ID
ZDB-GENE-060503-526
Name
vacuolar protein sorting 45 homolog
Symbol
vps45 Nomenclature History
Previous Names
  • si:dkey-200h23.3
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Involved in regulation of lens fiber cell differentiation. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
rw341Allele with one insertionUnknownUnknownENU
sa14216Allele with one point mutationUnknownPremature StopENU
sa45682Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-vps45N/AVilboux et al., 2013
MO2-vps45N/AVilboux et al., 2013
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Human Disease
Associated With vps45 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
severe congenital neutropenia 5 Alliance Neutropenia, severe congenital, 5, autosomal recessive 615285
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Associated With vps45 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001619 Sec1-like protein
Homologous_superfamily IPR027482 Sec1-like, domain 2
Homologous_superfamily IPR036045 Sec1-like superfamily
Homologous_superfamily IPR043127 Sec1-like, domain 3a
Homologous_superfamily IPR043154 Sec1-like, domain 1
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Domain Details Per Protein
Protein Length Sec1-like, domain 1 Sec1-like, domain 2 Sec1-like, domain 3a Sec1-like protein Sec1-like superfamily
UniProtKB:A8E7N5 568
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA vps45-201 (1) Ensembl 2,518 nt
ncRNA vps45-002 (1) Ensembl 645 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(cryaa:vps45-GFP)
  • Danio rerio
1Mochizuki et al., 2018
Tg(foxe3:vps45-GFP)
  • Danio rerio
1Mochizuki et al., 2018
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-200H23ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanVPS451
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseVps453
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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