Gene
plch1
- ID
- ZDB-GENE-060503-398
- Name
- phospholipase C, eta 1
- Symbol
- plch1 Nomenclature History
- Previous Names
-
- si:ch211-203b20.8
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Is expressed in brain and liver. Orthologous to human PLCH1 (phospholipase C eta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Jelen et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Holoprosencephaly 14 | 619895 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
Domain | IPR000008 | C2 domain |
Domain | IPR000909 | Phosphatidylinositol-specific phospholipase C, X domain |
Domain | IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
Domain | IPR001849 | Pleckstrin homology domain |
Domain | IPR002048 | EF-hand domain |
Domain | IPR015359 | Phosphoinositide-specific phospholipase C, EF-hand-like domain |
Domain | IPR028392 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, catalytic domain |
Domain | IPR046972 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, EF-hand motif |
Family | IPR001192 | Phosphoinositide phospholipase C family |
Homologous_superfamily | IPR011992 | EF-hand domain pair |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Homologous_superfamily | IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
Protein | Length | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, catalytic domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, EF-hand motif | C2 domain | C2 domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phosphoinositide-specific phospholipase C, EF-hand-like domain | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PMN2
|
1753 | ||||||||||||||
UniProtKB:A0A8M6Z2T4
|
980 | ||||||||||||||
UniProtKB:A0A8M9PFX4
|
1765 | ||||||||||||||
UniProtKB:A0A8M9PPN9
|
1735 | ||||||||||||||
UniProtKB:A0A8M9P1F6
|
1795 | ||||||||||||||
UniProtKB:A0A8M9PVZ6
|
1715 | ||||||||||||||
UniProtKB:A0A8M9PAI3
|
1775 | ||||||||||||||
UniProtKB:A0A8M6YTQ9
|
979 |
Interactions and Pathways
No data available
Plasmids
No data available